Implementation of regional innovation networks: a case study of the biotech industry in Campania
Purpose of the paper: The paper aims to investigate whether Distretto ad Alta Tecnologia Campania Bioscience – CB, an emergent regional innovation network promoted by the Campania Regional Authority, can become sustainable, i.e. whether it can achieve the expected results and last in the future.
Methodology: The work is based on a qualitative method – a single case study – and investigates the sustainability of CB in reference to three theoretical aspects: a) the structure of innovation networks and the linkages established within them; b) the external context; c) the advantages and disadvantages of being part of such networks.
Findings: The above theoretical aspects have been properly considered when implementing CB. Therefore, up to now, CB is a candidate for a sustainable regional innovation network.
Research limitations: CB is still in an embryonic phase. This exploratory study leads to results that need to be confirmed – or that might be denied – by future, longitudinal studies.
Implications: Policy makers aiming to implement new regional innovation networks could recall the best practices adopted by the Campania Regional Authority when implementing CB.
Originality/value of the paper: To our knowledge it is rare to find articles trying to test sustainability of regional innovation networks in reference to Italy. This work therefore represents one of the first attempts to do so.
Riferimenti bibliografici
ADLER P.S., KWON S.W. (2002), Social capital: prospects for a new concept, Academy of Management Review, vol. 27, n. 1, pp. 17-40.
AHUJA G. (2000), Collaboration networks, structural holes, and innovation: a longitudinal study, Administrative Science Quarterly, vol. 45, n. 3, pp. 425-455.
AMICO ROXAS S.A., PIROLI G., SORRENTINO M. (2011), Efficiency and evaluation analysis of a network of technology transfer brokers, Technology Analysis and Strategic Management, vol. 23, n. 1, pp. 7-24.
ARORA A., GAMBARDELLA A. (1990), Complementary and external linkages: the strategies of the large firms in biotechnology, The Journal of Industrial Economics, vol. 38, n. 4, pp. 361-379.
ARRANZ N., DE ARROYABE J.C. (2012), Can innovation network projects result in efficient performance?, Technological Forecasting and Social Change, vol. 79, n. 3, pp. 485-497.
AUDRETSCH D.B., FELDMAN M.P. (2003), Small-firm strategic research partnership: the case of biotechnology, Technology Analysis and Strategic Management, vol. 15, n. 2, pp. 273-288.
BARNES W., GARTLAND M., STACK M. (2004), Old Habits Die Hard: Path Dependency and Behavioral Lock-in, Journal of Economic Issues, vol. 28, n. 2, pp. 371-377.
BATHELT H., MALMBERG A., MASKELL P. (2004), Clusters and knowledge: local buzz, global pipelines and the process of knowledge creation, Progress in Human Geography, vol. 28, n. 1, pp. 31-56.
BAUM J.A.C., CALABRESE T., SILVERMAN B.S. (2000), Dont go it alone, alliance network composition and start-ups performance in Canadian biotechnology, Strategic Management Journal, vol. 21, n. 3, pp. 267-294.
BIRLEY S. (1985), The role of networks in the entrepreneurial process, Journal of Business Venturing, vol. 3, n. 1, pp. 107-117.
BLOCK Z., MACMILLAN I.C. (1993), Corporate Venturing: Creating New Businesses within the Firm, Harvard Business School Press, Boston.
BOARDMAN P.C. (2008), Beyond the stars: the impact of affiliation with university biotechnology centres on the industrial involvement of university scientists, Technovation, vol. 28, n. 5, pp. 291-297.
BRAMWELL A., WOLFE D.A. (2008), Universities and regional economic development: the entrepreneurial university of Waterloo, Research Policy, vol. 37, n. 8, pp. 1175-1187.
BURGELMAN R.A. (1983), A process model of internal corporate venturing in the diversified major firm, Administrative Science Quarterly, vol. 28, n. 2, pp. 223-244.
BURT R. (1992), Structural Holes: The Social Structure of Competition, Harvard University Press, Cambridge.
BURT R. (2000), The network structure of social capital, in Sutton R. (Ed.), Research in Organizational Behaviour, JAI Press, Greenwich.
CASPER S. (2007), How do technology clusters emerge and become sustainable? Social network formation and inter-firm mobility within the San Diego biotechnology cluster, Research Policy, vol. 36, n. 4, pp. 438-455.
CHESBROUGH H. (2003), Open innovation: The new imperative for creating and profiting from technology, Harvard Business School Press, Cambridge, MA.
CHESBROUGH H., CROWTHER A.K. (2006), Beyond high tech: early adopters of open innovation in other industries, R&D Management, vol. 36, n. 3, pp. 229-236.
CHIARONI D., CHIESA V. (2006), Forms of creation of industrial clusters in biotechnology, Technovation, vol. 26, n. 9, pp. 1064-1076.
CHIESA V., PICCALUGA A. (2000), Exploitation and diffusion of public research: The case of academic spin-off in Italy, R&D Management, vol. 30, n. 4, pp. 329-339.
COHEN W.M., LEVINTHAL D.A. (1990), Absorptive capacity: a new perspective on learning and innovation, Administrative Science Quarterly, vol. 35, n. 1, pp. 128-152.
COOKE P. (2002), Knowledge economies: Cluster, learning and cooperative advantage, Routledge, New York.
COOKE P. (2005), Rational drug design, the knowledge value chain and bioscience megacentres, Cambridge Journal of Economics, vol. 29, n. 3, pp. 325-341.
COOKE P., KAUFMANN D., LEVIN C., WILSON R. (2006), The biosciences knowledge value chain and comparative incubation models, Journal of Technology Transfer, vol. 31, n. 1, pp. 115-129.
COOKE P., MORGAN K. (1998), The Associational Economy: Firms, Regions, and Innovation, Oxford Economic Press, Oxford.
COOKE P., URANGA M., ETXEBARRIA G. (1997), Regional innovation systems: institutional and organizational dimensions, Research Policy, vol. 26, n. 4-5, pp. 475-491.
CORSARO D., RAMOS C., HENNEBERG S., NAUD P. (2012), The impact of network configurations on value constellations in business markets – The case of an innovation network, Industrial Marketing Management, vol. 41, n. 1, pp. 54-67.
COWAN R. (1990), Nuclear power reactors: A study in technological lock-in, The Journal of Economic History, vol. 50, n. 3, pp. 541-567.
CUNNINGHAM B.C. (2002), Biotech and pharma: State of the relationship in the new millennium, Drug development research, vol. 57, n. 2, pp.97-102.
DAHLANDER L., GANN D.M. (2010), How open is innovation?, Research Policy, vol. 39, n. 6, pp. 699-709.
DAVID P.A. (2000), Path-dependence, its critics and the quest for historical economics, in Garrouste P., Ioannides S. (eds.), Evolution and Path Dependence in Economic Ideas: Past and Present, Edward Elgar Publishing, Cheltenham, England.
DOLOREUX D. (2002), What should we know about regional systems of innovation?, Technology in Society, vol. 24, n. 3, pp. 243-263.
DYER W.G., WILKINS A.L. (1991), Better Stories, Not Better Constructs, to Generate Better Theory: A Rejoinder to Eisenhardt, The Academy of Management Review, vol. 16, n. 3, pp. 613-619.
EISENHARDT K.M. (1989), Building Theories from Case Study Research, Academy of Management Review, vol. 14, n. 4, pp. 532-550.
EISENHARDT K.M., GRAEBNER M.E. (2007), Theory building from cases: Opportunities and challenges, The Academy of Management Journal, vol. 50, n. 1, pp. 25-32.
ELFRING T., HULSINK W. (2003), Networks in entrepreneurship: The case of high-technology firms, Small Business Economics, vol. 21, n. 4, pp. 409-422.
ERNST & YOUNG (2014), Rapporto sulle Biotecnologie in Italia – BioinItaly Report 2014.
ETZKOWITZ H. (2003), Research groups as quasi-firms: the invention of the entrepreneurial university, Research Policy, vol. 32, n. 1, pp. 109-121.
ETZKOWITZ H., LEYDESDORFF L. (1999), The future location of research and technology transfer, Journal of Technology Transfer, vol. 24, n. 2, pp. 111-123.
ETZKOWITZ H., LEYDESDORFF L. (2000), The dynamics of innovation: From national systems and mode 2 to a triple helix of university-industry-government relations, Research Policy, vol. 29, n. 2, pp. 109-123.
ETZKOWITZ H., WEBSTER A., GEBHARDT C., TERRA B. (2000), The future of the university and the university of the future: Evolution of ivory tower to entrepreneurial paradigm, Research Policy, vol. 29, n. 3, pp. 313-330.
FREEMAN C. (1991), Networks of innovators: a synthesis of research issue, Research Policy, vol. 20, n. 5, pp. 499-514.
GAMBARDELLA A. (1995), Science and innovation. The US Pharmaceutical industry during the 1980s, Cambridge University Press, Cambridge.
GANS J.S., STERN S. (2003), The Product Market and the Market for Ideas: Commercialization Strategies for Technology Entrepreneurs, Research Policy, vol. 32, n. 2, pp. 333-350.
GILDING M. (2008), The tyranny of distance: Biotechnology networks and Clusters in the antipodes, Research Policy, vol. 37, n. 6, pp. 1132-1144.
GMEZ GRAS J.M., GALIANA LAPERA D.R., MIRA SOLVES I., VERDU JOVER A.J., SANCHO AZUAR J. (2008), An Empirical Approach To The Organizational Determinants Of Spin-Off Creation In European Universities, International Entrepreneurship And Management Journal, vol. 4, n. 2, pp. 187-198.
GRANOVETTER M. (1973), The strength of weak ties, American Journal of Sociology, vol. 78, n. 6, pp. 1360-1380.
GRANOVETTER M. (1985), Economic Action and Social Structure: The Problem of Embeddedness, American Journal of Sociology, vol. 91, n. 3, pp. 481-510.
GREVE A. (1995), Networks and Entrepreneurship – An Analysis of Social Relations, Occupational Background, and the Use of Contacts during the Establishment Process, Scandinavian Journal of Management, vol. 11, n. 1, pp. 1-24.
GREVE A., SALAFF J.W. (2003), Social networks and entrepreneurship, Entrepreneurship: Theory and Practice, vol. 28, n. 1, pp. 1-22.
GULATI R. (1998), Alliances and networks, Strategic Management Journal, vol. 19, n. 4, pp. 293-317.
GULATI R., NOHRIA N., ZAHEER A. (2000), Strategic networks, Strategic Management Journal, vol. 21, n. 3, pp. 203-215.
HAGEDOORN J. (1993), Understanding the rationale of strategic technology partnering: Inter-organizational modes of cooperation and sectoral differences, Strategic Management Journal, vol. 14, n. 5, pp. 371-385.
HAGEDOORN J. (2002), Inter-firm R&D partnership: an overview of major trends and patterns since 1960, Research Policy, vol. 31, n. 4, pp. 477-492.
HAGEDOORN J., LINK A.N., VONORTAS N.S. (2000), Research partnership, Research Policy, vol. 29, n. 4-5, pp. 567-586.
HAMEL G. (1991), Competition for competence and inter-partner learning within international strategic alliances, Strategic Management Journal, vol. 12, Summer Special Issue, pp. 83-103.
HAMEL G., DOZ Y., PRAHALAD C.K. (1989), Collaborate with your competitors and win, Harvard Business Review, vol. 67, n. 1, pp. 133-139.
HANNAN M.T., FREEMAN J. (1984), Structural inertia and organizational change, American Sociological Review, vol. 49, n. 2, pp. 149-164.
HUIZINGH E.K. (2011), Open innovation: State of the art and future perspectives, Technovation, vol. 31, n. 1, pp. 2-9.
JENSEN M., MECKLING W. (1976), Theory of the firm: managerial behaviour, agency costs and ownership structure, Journal of Financial Economics, vol. 3, n. 4, pp. 305- 360.
JOHANNISSON B. (1998), Personal Networks in Emerging Knowledge-based firms: Spatial and Functional Patterns, Entrepreneurship and Regional Development, vol. 10, n. 4, pp. 297-312.
JOHNSON W.H.A. (2008), Roles, resources and benefits of intermediate organizations supporting triple helix collaborative R&D: the case of Precarn, Technovation, vol. 28, n. 8, pp. 495-505.
KATZ M., SHAPIRO C. (1985), Network Externalities, Competition, and Compatibility, American Economic Review, vol. 75, n. 3, pp. 424-440.
KEEBLE D., LAWSON C., MOORE B., WILKINSON F. (1999), Collective learning processes, networking and institutional thickness in the Cambridge region, Regional Studies, vol. 33, n. 4, pp. 319-332.
KHANNA T., GULATI R., NOHRIA N. (1998), The dynamics of learning alliances: Competition, cooperation and relative scope, Strategic Management Journal, vol. 19, n. 3, pp. 193-210.
KOGUT B. (1989), The stability of joint ventures: reciprocity and competitive rivalry, The Journal of Industrial Economics, vol. 38, n. 2, pp. 183-198.
LAURSEN K., SALTER A. (2006), Open for innovation: the role of openness in explaining innovation performance among UK manufacturing firms, Strategic Management Journal, vol. 27, n. 2, pp. 131-150.
LAWSON C., LORENZ C. (1999), Collective learning, tacit knowledge and regional innovative capacity, Regional Studies, vol. 33, n. 4, pp. 305-317.
LAZONICK W., TULUM . (2011), US biopharmaceutical finance and the sustainability of the biotech business model, Research Policy, vol. 40, n. 9, pp. 1170-1187.
LEE B., COLLIER P.M., CULLEN J. (2007), Reflections on the use of case studies in the accounting, management and organizational disciplines, Qualitative Research in Organizations and Management: An International Journal, vol. 2, n. 3, pp. 169-178.
LIPPARINI A., SOBRERO M. (1994), The glue and the pieces: Entrepreneurship and innovation in small-firm networks, Journal of Business Venturing, vol. 9, n. 2, pp. 125-140.
LOCKETT A., WRIGHT M. (2005), Resources, Capabilities, Risk Capital And The Creation Of University Spin-Out Companies, Research Policy, vol. 34, n. 7, pp. 1043-1057.
LUNDGREN A. (1995), Technological Innovation and Network Evolution, Routledge, New York.
MATRICANO D. (2011), Lorigine delle opportunit imprenditoriali nelle reti di imprese, in Izzo F. (ed.), Reti per linnovazione, McGraw Hill, Milano.
NEERGARD H. (2005), Networking activities in technology-based entrepreneurial teams, International Small Business Journal, vol. 23, n. 3, pp. 257-278.
OSHEA R., ALLEN T., CHEVALIER A., ROCHE F. (2005), Entrepreneurial Orientation, Technology Transfer And Spin-Off Performances Of U.S. Universities, Research Policy, vol. 34, n. 7, pp. 994-1009.
ORSENIGO L. (2001). The (failed) development of a biotechnology cluster: The case of Lombardy, Small Business Economics, vol. 17, n. 1-2, pp. 77-92.
ORSENIGO L., PAMMOLLI F., RICCABONI M. (2001), Technological change and network dynamics. Lessons from the pharmaceutical industry, Research Policy, vol. 30, n. 3, pp. 485-508.
OSBORN R.N., HAGEDOORN J. (1997), The institutionalism and evolutionary dynamics of inter-organizational alliances and networks, Academy of Management Journal, vol. 40, n. 2, pp. 261- 278.
PARTANEN J., CHETTY S., RAJALA A. (2011), Innovation types and network relationships, Entrepreneurship: Theory and Practice, vol. 38, n. 5, pp. 1027-1055.
PHAN P., SIEGEL D.S. (2006), The effectiveness of university technology transfer, Foundations and Trends in Entrepreneurship, vol. 2, n. 2, pp. 66-144.
PISANO G.P. (2006), Science Business: The Promise, Reality and Future of Biotech, Harvard Business School Press, Cambridge, MA.
PISANO G.P., SHUEN W., TEECE D.J. (1988), Joint ventures and collaboration in the biotechnology industry, in Mowery D.C. (ed.), International Collaborative Ventures in US Manufacturing, Ballinger, Cambridge, MA.
PITT L., VAN DER MERWE R., BERTHON P., SALEHI-SANGARI E., CARUANA A. (2006), Global alliance networks: A comparison of biotech SMEs in Sweden and Australia, Industrial Marketing Management, vol. 35, n. 5, pp.600-610.
PITTAWAY L., ROBERTSON M., MUNIR K., DENYER D., NEELY A. (2004), Networking and innovation: A systemic review of the evidence, International Journal of Management Reviews, vol. 5/6, pp. 137-168.
PODOLNY J.M., BARON J.N. (1997), Resources and Relationships: Social Networks and Mobility in the Workplace, American Sociological Review, vol. 62, n. 5, pp. 673-693.
POWELL W. (1998), Learning from collaboration: knowledge networks in biotechnology and pharmaceutical industries, California Management Review, vol. 40, n. 3, pp. 228-240.
POWELL W., KOPUT K., SMITH-DOERR L. (1996), Inter-organizational collaboration and the locus of innovation: networks of learning in biotechnology, Administrative Science Quarterly, vol. 41, n. 1, pp. 116-145.
RICCIARDI A. (2006), Le reti di imprese, in Izzo F., Ricciardi A. (eds.), Relazioni di Cooperazione e Reti di Imprese. Il Caso della Campania, Franco Angeli, Milano.
RICKNE A. (2006), Connectivity and performance of science-based firms, Small Business Economics, vol. 26, n. 4, pp. 393-407.
ROIJAKKERS N., HAGEDOORN J., VAN KRANENBURG H. (2005), Dual market structures and the likelihood of repeated ties: Evidence from pharmaceutical biotechnology, Research Policy, vol. 34, n. 2, pp. 235-245.
ROTHAERMEL F.T. (2001a), Complementary assets, strategic alliances, and the incumbents advantage: an empirical study of industry and firm effects in the biopharmaceutical industry, Research Policy, vol. 30, n. 8, pp. 1235- 1251.
ROTHAERMEL F.T. (2001b), Incumbents advantage through exploiting complementary assets via interfirm cooperation, Strategic Management Journal, vol. 22, Special Issue, pp. 687-699.
RYCROFT R., KASH D. (2004), Self-organizing innovation network: implications for globalization, Technovation, vol. 24, n. 3, pp. 187-197.
SALAVISA I., SOUSA C., FONTES M. (2012), Topologies of innovation networks in knowledge-intensive sectors: sectoral differences in the access to knowledge and complementary assets through formal and informal ties, Technovation, vol. 32, n. 6, pp. 380-399.
SCOTT J. (1991), Social Network Analysis: A Hanbook, Sage Publications, London.
SHANE S. (2004), Encouraging university entrepreneurship? The effect of the Bayh-Dole Act on university patenting in the United States, Journal of Business Venturing, vol. 19, n. 1, pp. 127-151.
SHANE S., CABLE D. (2002), Network ties, reputation, and the financing of new firms, Management Science, vol. 48, n. 3, pp. 364-381.
SIEGEL D.S., WRIGHT M., LOCKETT A. (2007), The Rise Of The Entrepreneurial Activities At Universities: Organizational And Societal Implications, Industrial And Corporate Change, vol. 16, n. 4, pp. 489-504.
SORRENTINO F., GARRAFFO F. (2012), Explaining performing R&D through alliances: Implications for the business model of Italian dedicated biotech firms, Journal of Management and Governance, vol. 16, n. 3, pp. 449- 475.
SORRENTINO M., WILLIAMS M. (1995), Relatedness and corporate venturing: Does it really matter?, Journal of Business Venturing, vol. 10, n. 1, pp. 59-73.
SPITHOVEN A., CLARYSSE B., KNOCKAERT M. (2011), Building absorptive capacity to organise inbound open innovation in traditional industries, Technovation, vol. 31, n. 1, pp. 10-21.
STINCHCOMBE A.L. (1965), Social structure and organizations, in March J.G. (ed.), Handbook of Organizations, Rand McNally & Firm, Chicago.
STINCHCOMBE A.L. (2000), Social structure and organizations, Advances in Strategic Management, vol. 17, issue: Economics Meets Sociology in Strategic Management, pp. 229-259.
STUART T.E. (2000), Inter-organizational alliances and the performance of firms: A study of growth and innovation rates in high-technology industry, Strategic Management Journal, vol. 21, n. 8, pp. 791-811.
WEST J., BOGERS M. (2014), Leveraging external sources of innovation: a review of research on open innovation, Journal of Product Innovation Management, vol. 31, n. 4, pp. 814-831.
WILLIAMSON O.E. (1975), Markets and Hierarchies: Analysis and Antitrust Implications, Free Press, New York.
YIN R.K. (1994), Discovering the future of the case study method in evaluation research, Evaluation practice, vol. 15, n. 3, pp. 283-290.
ZANNI L., PUCCI T. (2012), Capacit interne, relazioni esterne e performance in un cluster emergente: unanalisi empirica nel settore Life Sciences, Atti del XXIV Convegno di Sinergie, 18-19 ottobre, Lecce.
ZHANG J., SOUITARIS V., SOH P., WONG P.K. (2008), A contingent model of network utilization in early financing of technology firms, Entrepreneurship: Theory and Practice, vol. 32, n. 4, pp. 593-613.